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Charlottesville, Va. – A subpar night for Virginia’s normally stingy defense didn’t get in the way of the second-ranked Cavaliers’ 13th straight victory.

Kyle Guy scored 22 points and Ty Jerome hit two big 3-pointers to stall a rally by hot-shooting Louisville in the closing minutes as Virginia padded its lead in the Atlantic Coast Conference with a 74-64 win Wednesday night.

Jerome finished with 16 points and Devon Hall shook off a bout with the flu to add 12 for the Cavaliers (21-1, 10-0 ACC). The Cavaliers also got a huge boost from seldom-used freshman Marco Anthony, who scored 10 points.

“I’m so happy for him to be able to see him go out there and play that well,” Hall said of Anthony. “I wasn’t really surprised because he works his butt off and he always says, ‘I’m just waiting on my moment.’ He did a great job tonight. He helped us. Big lift.”

Anthony was 4 for 6 from the field and said he wasn’t nervous.

“I’m real confident in myself because of the hard work I put in, so just being ready for the moment,” he said.

Virginia’s start is its best in ACC play since the 1980-81 team featuring sophomore Ralph Sampson won its first 12 games. The winning streak is Virginia’s longest since it won 19 in a row to begin the 2014-15 season.

The Cavaliers lead the nation in scoring defense (52.1 points per game) and are third in field-goal percentage defense (.370), but allowed the Cardinals to become the first team to make at least half their shots this year. Louisville was 25 for 50, 50 percent, and made eight 3-pointers.

“They exploited some things. We didn’t guard perfectly and they made us look out of position at times,” coach Tony Bennett said.

Virginia, however, was better, hitting 29 of 54 shots, 53.7 percent, including nine of 16 from 3-point territory.

“When they shoot the ball like that, you’re going to have to make more than eight threes to beat them,” Louisville coach David Padgett said. “It’s a game where you literally just have to tip your hat to the other team and just they just made big plays and big shots.”

Ray Spalding scored 16 points and Deng Adel had 15 points for the Cardinals (16-6, 6-3). Louisville made nine of 10 shots in one late stretch, closing to within 62-57 on a long 3-pointer by Ryan McMahon with 3:44 left, but Jerome answered with his long back-to-back 3s.

“Those were impressive shots,” Bennett said of Jerome’s 3-pointers, each of which was taken well behind the 3-point arc. “He just needs a little space and if you come in too close, he’ll get in the lane and make some tough shots.”

The victory gave Virginia a three-game lead in the conference.

More Top 25

(At) No. 8 Cincinnati 80, Houston 70: Jacob Evans III scored 18 points, hitting the pivotal shots during Cincinnati’s rally from an 18-point deficit, and the Bearcats extended the nation’s longest home-court winning streak at 38 games.

No. 9 Arizona 100, (at) Washington State 72:Deandre Ayton scored 25 points and grabbed 11 rebounds, and Allonzo Trier added 24 points as Arizona beat cold-shooting Washington State to remain in first place in the Pac-12.

(At) No. 10 Texas Tech 73, Texas 71, OT: Keenan Evans scored a career-high 38 points, including the winning jumper to beat the buzzer in overtime.

(At) Iowa State 93, No. 15 West Virginia: Donovan Jackson scored 25 points, Lindell Wigginton added 22 and Iowa State upset 15th-ranked West Virginia, sending the short-handed Mountaineers to their fifth loss in six games.

(At) No. 18 Tennessee 84, LSU 61: James Daniel III scored 17 points off the bench to continue his recent surge as No. 18 Tennessee trounced LSU for its fourth consecutive victory.

Big Ten

(At) Purdue 75, Maryland 67: Isaac Haas had 20 points and nine rebounds, Carsen Edwards scored 17 points and Purdue extended the nation’s longest active winning streak to 18.

The Boilermakers (22-2, 11-0 Big Ten) also continued their best conference start in school history, broke another school record with their 13th consecutive win over a league foe and still won their 21st straight home game. Only Cincinnati (38) has a longer home-court streak.

Bruno Fernando finished with 20 points and 10 rebounds to lead Maryland (15-9, 4-7). Kevin Huerter had 16 points and four 3s for the Terrapins, who have lost three straight with the last two coming to top-10 teams.

State women

(At) Central Michigan 86, Buffalo 79: Tinara Moore had 24 points — 12 on free throws — and Presley Hudson scored 22 for the Chippewas, now 17-3, 9-0 MAC. Cierra Dillard led Buffalo (16-4, 7-2 MAC) with 22 points.

Toledo 78, (at) Western Michigan 73: The Broncos (12-10, 5-5 MAC) racked up 25 points in a fourth-quarter rally that ultimately fell short. Breanna Mobley totaled 20 points and Deja Wimby 19 in the losing effort. Jay Bravo-Harriott’s 24 points led Toledo (15-7, 6-4 MAC).

Report: Coach, son beat ref

A men’s college basketball coach and his adult son have been charged with attacking a referee following a game against a rival school in Wisconsin.

University of Wisconsin-Rock County coach Jamal Mosley and his 20-year-old son, J’shon Mosley, are charged with battery and disorderly conduct. The younger Mosley is a manager.

They’re accused of tracking down the referee after the team’s loss on Jan. 3, and beating him as he fell to the ground. Investigators say witnesses stopped the attack and called police.

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