Doc: Though rare, medication can be cause of ED

Keith Roach
To Your Health

Dear Dr. Roach: I am a man, 77, who has had erectile dysfunction for eight years. I’ve been on the following medications for 12 years: atenolol, lisinopril and amlodipine for high blood pressure; metformin and glipizide for Type 2 diabetes. Recent lab results have shown normal testosterone level, A1C reading of 6 and BP of 128/78. Could there be a relationship between my medications and my ED?


Dear R.F.: Erectile dysfunction is a common problem in men, and is increasingly prevalent as men get older. Sometimes a cause is found, but often there isn’t. When there is a cause that’s found, it sometimes is due to medicine, but also can be traced to poor blood flow, damage to nerves, abnormal hormone levels or psychological factors.

Poor blood flow in large blood vessels can cause ED. This means treatment is important, because men with blockages in the blood supply to the penis also may have blockages in the blood supply to the heart or brain, so it’s worth considering. Men with high blood pressure and diabetes are at higher risk for arterial blockages.

Nerve damage can be due to trauma or nerve diseases. Diabetes increases the risk of all kinds of nerve diseases, but your A1C level indicates that you have good control of your diabetes, which makes this unlikely. A careful physical exam can answer this question.

Testosterone levels frequently are abnormal in older men, but one other hormone I recommend checking in men with ED is prolactin: It can be a cause of ED, although rare. It can be produced by brain tumors.

Psychological factors are the hardest to diagnose, but many of us physicians forget to even ask.

If there are no clear reasons for ED, then I certainly would evaluate the medicines you are taking. Of your medications, atenolol is the most often reported to be associated with ED, but lisinopril and amlodipine also may cause it. Stopping the medicine may solve the problem; unfortunately, after eight years, the odds of being able to reverse the condition become less likely.

Dear Dr. Roach: I’ve read questions and answers in your column on testosterone gel application. Is it acceptable to apply it to the upper legs, above the knees, on the inside of the thighs?


Dear D.P.: There are four different testosterone gel preparations, and they all have specific instructions, which need to be followed for consistent results. For example, AndroGel is absorbed 30 percent better when applied to the arms and shoulders than to the abdomen. Fortesta is recommended to be applied to the front and inner thighs, and Axiron is supposed to be applied to the underarms. I recommend following the manufacturer’s directions, as absorption can be variable.

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