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Miami — Federal authorities have told blood centers in two Florida counties to suspend collections amid investigations into four mysterious cases of Zika infection that may be the first spread by mosquitoes on the U.S. mainland.

Blood centers in the Miami and Fort Lauderdale areas were asked to immediately stop collecting blood until they can screen each unit of blood for the Zika virus with authorized tests, according to a statement on the U.S. Food and Drug Administration website.

Florida health officials have said the infections in Miami-Dade and Broward counties may not be linked to travel outside the U.S., but they have not confirmed how the virus spread.

Investigators are going door-to-door in the affected areas to talk with residents and collect samples. No mosquitoes collected from those areas so far have tested positive for Zika, said Jennifer Meale, spokeswoman for the state’s Department of Agriculture and Consumer Services.

The FDA recommends that neighboring counties also implement the same precautions “to help maintain the safety of the blood supply as soon as possible.”

Visitors to South Florida in the last month are being urged to defer donations as well.

The FDA previously advised U.S. blood banks to refuse donations from people who recently travelled to areas outside the country that have Zika outbreaks.

Florida’s main supplier of blood said it was working as quickly as possible to comply with the FDA’s “unanticipated” request and would start testing all its collections for Zika on Friday.

OneBlood suspended collections earlier this week in the areas of Miami-Dade and Broward counties that are being investigated, according to a statement released Thursday.

The FDA is working with companies making the blood screening tests available to expand their operations, and blood centers nationwide can do this testing even without the transmission of Zika by local mosquitoes, Peter Marks, director of the FDA’s Center for Biologics Evaluation and Research, said in a statement Thursday.

Blood banks in Texas and Hawaii have begun or soon will start testing blood donations for the Zika virus. Puerto Rico suspended blood donations and imported blood products for the month of March until U.S. health officials approved the use of an experimental test to screen blood donations for the virus.

Messages left Thursday for officials at the Florida Department of Health were not returned.

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