Tuscaloosa, Ala. — Neither Florida's defense nor Alabama's mistakes could contain Blake Sims and Amari Cooper.

Sims threw for 445 yards, the second-best passing performance in school history, and Cooper scored three touchdowns as the third-ranked Crimson Tide overcame a sloppy performance to beat the Gators 42-21 on Saturday.

The Tide (4-0, 1-0 SEC) committed 11 penalties for 80 yards and four turnovers that turned into 21 points for the Gators (2-1, 1-1), who still couldn't handle Sims and the prolific passing connection.

Sims threw touchdown passes of 87 yards to Kenyan Drake on the opening play and 79 to Cooper later in the first quarter. Still, 400 yards for an Alabama offense known more in the past for bruising running games?

"I didn't think it was possible," Sims said. "I just try to take what I take and what the defense gives me, and just try to trust my guys that they're going to be there."

Cooper, who came in leading the nation in receptions, caught 10 passes for 201 yards and three touchdowns. He broke Dennis Homan's 47-year-old record of 18 career touchdown catches.

The Tide's turnovers and miscues kept the game close into the fourth quarter. Alabama's 645 total yards was the most the Gators have allowed.

The previous high was Nebraska's 629 yards in the 1996 Fiesta Bowl. Sims was 23-of-33 passing with four touchdowns, and was already up to 335 by halftime. That placed him a yard shy of the Tide's Top 10 passing games.

"People have to respect his passing," Tide coach Nick Saban said. "He has made too many plays for people not to respect him as a passer."

Derrick Henry gained 111 yards on 20 rushes.

Sims deflected much of the credit, saying that when you have Alabama's offensive line, receivers and tailbacks, "You're bound to have a good game."

The Gators' offense wasn't much more successful than its defense.

Florida's Jeff Driskel was harassed and ineffective passing. He was 9-of-28 passing for 93 yards and was intercepted twice while the offense produced just 200 yards.

Driskel did run for 59 yards, but it got so bad that Florida legend Emmitt Smith called for the quarterback's benching on Twitter.

Demarcus Robinson, who had 15 catches in an overtime win over Kentucky, was held to two receptions for 14 yards.

Florida failed in its bid for a statement-making performance after a 4-8 season and to perhaps lift coach Will Muschamp, whose mentor Saban was on the opposite sideline, from the hot seat. The Tide's blunders kept the game from being even more lopsided.

"We had our chances and we didn't do it," Muschamp said. "That's the frustrating thing."

No. 2 Oregon 38, (at) Washington State 31: Marcus Mariota threw for 329 yards and five touchdowns. Devon Allen and Keanon Lowe each had two touchdown receptions for Oregon (4-0, 1-0 Pac-12), which has won eight straight games against Washington State.

Connor Halliday threw for 436 yards and four touchdowns for Washington State (1-3, 0-1), which boasts the nation's top passing attack. They came into the game as 24-point underdogs, but stayed close the entire way.

No. 4 Oklahoma 45, (at) West Virginia 33: Bruising freshman Samaje Perine rushed for 242 yards and four touchdowns to lead Oklahoma. Alex Ross scored on a 100-yard kickoff return and quarterback Trevor Knight caught a 4-yard scoring pass on a trick play for the Sooners (4-0, 1-0 Big 12).

Oklahoma won its eighth straight game dating to last season and its 11th road game in 12 tries.

Perine had second-half scoring runs of 9, 5 and 19 yards as the Sooners pulled away after the game was tied 24-24 at halftime.

No. 6 Texas A&M 58, (at) SMU 6: Kenny Hill had 322 yards of total offense playing only the first half, and Jeremy Tabuyo turned two short passes into touchdowns for Texas A&M.

Trey Williams ran for two touchdowns for the Aggies, who last started 4-0 in 2006. The Mustangs (0-3) played for the first time since coach June Jones resigned two games into his seventh season.

Hill, the sophomore who succeeded 2012 Heisman Trophy winner Johnny Manziel as the starting quarterback, completed 16 of 22 passes for 265 yards with two touchdowns and his first interception at Texas A&M. His 58-yard run set up another touchdown as the Aggies built a 38-3 halftime lead.

Mississippi State 34, (at) No. 8 LSU 29: Dak Prescott highlighted a dynamic performance with two touchdown passes and 56-yard scoring run, and Mississippi State held off a wild rally by the Tigers. The Bulldogs snapped a 14-year losing streak in the series.

MSU led 34-10 in the fourth quarter, but LSU scored three late touchdowns. That set up a last-second desperation heave by LSU backup quarterback Brandon Harris, which was intercepted by Will Redmond at the goal line.

Prescott, a Louisiana native, finished with 268 yards passing and 105 yards rushing while helping the Bulldogs (4-0) not only beat LSU (3-1) for the first time since 1999, but win in Tiger Stadium for the first time since 1991 — about two years before Prescott was born.

His touchdown passes went for 74-yards to Jameon Lewis and 9 yards to De'Runnya Wilson. Josh Robinson rushed for 197 yards and a touchdown.

(At) No. 13 Georgia 66, Troy 0: Sony Michel ran for 155 yards and three touchdowns for the host Bulldogs. Michel, a freshman playing behind Todd Gurley, had a 75-yard gain to set up his second touchdown.

Among other standout freshmen for Georgia (2-1) were receiver Isaiah McKenzie, who scored on a 52-yard punt return, and Bryce Ramsey, who threw his first career touchdown pass.

Dontreal Pruitt started at quarterback for Troy (0-4) as Brandon Silvers was held out after leaving last week's loss to Abilene Christian with a concussion. The Trojans' last 0-4 start was in 1982.

No. 14 South Carolina 48, (at) Vanderbilt 34: Dylan Thompson threw for 237 yards and three touchdowns, and he ran for another score as South Carolina rallied from 14 points down.

South Carolina coach Steve Spurrier now has 202 SEC wins, breaking a tie with Vince Dooley and putting him second only to Paul "Bear" Bryant (292). Spurrier also got his 20th win all-time against the Commodores.

The Gamecocks (3-1, 2-1) started slow coming off their 38-35 win over Georgia in their first road trip this season. They got going by scoring 17 points in the second quarter as part of 24 straight points giving them the lead for good in beating Vanderbilt for a sixth straight time in this series.

(At) No. 21 BYU 41, Virginia 33: Taysom Hill threw two touchdown passes and ran for a score in BYU's comeback victory.

The Cougars (4-0) trailed 16-13 at the half and lagged behind the Cavaliers (2-2) in almost every statistical category, but turned around the game around with two third-quarter touchdowns.

Adam Hine sealed the victory with a 99-yard kickoff return midway through the final quarter.

Hill, averaging nearly 230 yards passing and 130 yards rushing, completed 13 of 23 for 187 yards and rushed for another 72 on 17 carries. He had only 29 yards rushing in the first half.