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Michigan State likely isn’t looking past its season opener against Jacksonville State tonight, but handicappers already are.

Online oddsmaker Pregame.com has listed Oregon, which will host Michigan State on Sept. 6, as a 13-point favorite to beat the Spartans. The matchup is considered one of the biggest early games of the college football season.

Both schools are contenders to make the playoffs this season. Pregame.com lists Oregon as an 8/1 favorite to win the inaugural College Football Playoff, while MSU has 30/1 odds.