Matt Charboneau: Michigan State took out its frustration last week against Eastern Michigan and will look to do the same this week against Wyoming with Big Ten play beginning next week against Nebraska. The Cowboys are a mirror image of the Spartans in many ways and will prove a solid tune-up in the final non-conference game of the season. It won't be as one-sided as a week ago, but the Spartans should still win comfortably. Michigan State 45-14

Angelique S. Chengelis: So, Wyoming wants to be an offense that features a power run game, a strong defense and overall is mistake-free. Basically, Wyoming wants to be Michigan State. With that in mind, not to mention the fact Michigan State destroyed Eastern Michigan last week as expected, the Spartans will prevail again. Michigan State 35-10

Bob Wojnowski: Michigan State can't get comfortable against another big underdog. Wyoming has a tough, veteran defense, but also has a ponderous, low-scoring offense. If the Spartans don't mess around, they'll do what they do and shut down the Cowboys. Michigan State 38-6

John Niyo: The Spartans probably can't count on another half-dozen turnovers this week. Or playing five different quarterbacks, for that matter. But against Wyoming, which hasn't beaten a ranked team since 2002, Michigan Sate's offensive line gets another chance to grow. Michigan State 38-13