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Glendale, Ariz. — The Arizona Cardinals dominated another opponent on Sunday, and the San Francisco 49ers had another long afternoon.

Especially Colin Kaepernick.

Carson Palmer threw for 311 yards and Arizona returned two of Kaepernick’s first four passes for touchdowns and the Cardinals romped past the San Francisco 49ers, 47-7.

Larry Fitzgerald caught nine passes for 134 yards and two touchdowns and Chris Johnson rushed for 110 yards and two scores for the Cardinals (3-0).

It’s the first time the franchise has had two 40-point victories in a row since 1969 and its largest margin of victory since a 44-0 win over Houston in 1970.

Kaepernick threw a career-worst four interceptions, two by Tyrann Mathieu, and finished 9-for-19 for 67 yards, a quarterback rating of 16.7.

The Cardinals scored 24 points off the four interceptions and opened an early two-game lead in the NFC West.

Palmer won his ninth straight game, the NFL’s longest active streak, and is 16-2 in his past 18 starts.

(At) Carolina 27, New Orleans 22: Cam Newton threw for 315 yards and a pair of touchdowns to tight end Greg Olsen and also ran for a score.

Newton ran for a 13-yard TD on a bootleg as the Panthers started 3-0 for the first time since reaching the Super Bowl in the 2003 season.

The Saints, playing without Drew Brees for the first time since 2006, fell to 0-3.

Cincinnati 28, (at) Baltimore 24: Andy Dalton kept the Bengals unbeaten and dropped the Ravens to 0-3 for the first time in franchise history.

The Bengals (3-0) blew a 14-0 lead and twice trailed in the fourth quarter before Dalton brought them back by repeatedly picking apart the porous Baltimore pass defense.

Dalton went 20-for-32 for 383 yards and three touchdowns. His favorite target was Green, who finished with 10 catches for a career-high 227 yards and two scores.

Baltimore was the only existing NFL team never to start 0-3.

Indianapolis 35, (at) Tennessee 33: Andrew Luck threw two touchdown passes 56 seconds apart in the fourth quarter as he rallied the Colts to their first in this season.

The Colts (1-2) trailed 27-14 before Luck got going, and Luck improved to 7-0 against Tennessee.

He drove the Colts 98 yards before hitting Phillip Dorsett on a 35-yard TD with 6:49 left. Luck found Donte Moncrief for an 11-yard TD for a 28-17 lead just 56 seconds later.

Pittsburgh 12, (at) St. Louis 6: With Ben Roethlisberger out injured, the Steelers needed their star running back and their defense to step up.

Le’Veon Bell (Michigan State) scored from a yard out in the first half in his first game back after a suspension, and Will Allen’s interception with 1:56 left set up a field goal by Josh Scobee to put Pittsburgh ahead by six points.

The Rams (1-2) were limited to two field goals by Greg Zuerlein and have scored just 16 points the last two games.

Steelers backup quarterback Michael Vick was 5-of-6 for 38 yards and had two carries for minus-2 yards in relief of Roethlisberger.

(At) Houston 19, Tampa Bay 9: Ryan Mallett (Michigan) and Alfred Blue helped the Texans to their first win on a day the Bucs were hampered by kicking problems.

Mallett threw for threw for 228 yards and a touchdown and Blue had 139 yards rushing with a score to lead the Texans (1-2).

The Buccaneers (1-2) went up 9-7 on a touchdown reception by Charles Sims in the second quarter that came after an interception by Mallett, but didn’t score again. Kyle Brindza (Plymouth High), who made a 58-yard field goal early in the second quarter, missed an extra point and three field goals in the second half.

Oakland 27, (at) Cleveland 20: Derek Carr threw two touchdown passes, Latavius Murray rushed for 139 yards and Oakland snapped an 11-game road losing streak.

Carr connected with Andre Holmes and Seth Roberts in the first half and the Raiders (2-1) held off a late Cleveland comeback to win their first road game since Nov. 17, 2013. Oakland also ended a 16-game losing streak in the Eastern time zone.

The Browns (1-2) were driving for a tying TD in the final minute, but veteran Charles Woodson (Michigan) intercepted Josh McCown with 38 seconds left. Woodson has at least one pick in each of his 18 NFL seasons.

Philadelphia 24, (at) N.Y. Jets 17: Darren Sproles sparked the Eagles with an 89-yard punt return for a score and added a 1-yard touchdown run, the defense caused four turnovers and Philadelphia got its first win of the season.

Sam Bradford threw a TD pass to Ryan Mathews, who also rushed for 108 yards on 25 carries while starting in place of injured DeMarco Murray. The Eagles (1-2) improved to 10-0 all-time against the Jets (2-1).

(At) Minnesota 31, San Diego 14: Adrian Peterson plowed through San Diego’s defense for 126 yards and two touchdowns on 20 rushes in three quarters on Sunday, and the Vikings trampled Philip Rivers and the injury-depleted Chargers.

Hours after his wife, Ashley, gave birth to their son, Axyl, Peterson crossed the goal line for the first time in more than 22 months.

Chad Greenway scored on a 91-yard interception return for the Vikings (2-1), who improved to 7-3 at home under coach Mike Zimmer.

Rivers was pulled for Kellen Clemens midway through the fourth quarter when the deficit reached 24 points. Sacked four times for a loss of 28 yards, Rivers went 21-for-34 for 246 yards with two turnovers and took a hard hit to the midsection from Anthony Barr in the third quarter.

(At) New England 51, Jacksonville 17: Tom Brady threw for two touchdowns and LeGarrette Blount scored on three 1-yard touchdown runs to help the defending Super Bowl champions run away from the Jaguars.

In all, Brady completed 33 of 42 passes for 358 yards. Rob Gronkowski caught four passes for 101 yards for the Patriots (3-0). Blount ran for 78 yards. Julian Edelman caught eight passes for 85 yards.

It was the most points ever allowed by the Jaguars (1-2).

Buffalo 41, (at) Miami 14: Tyrod Taylor threw for 277 yards and three scores in his first NFL road start Sunday. The Bills totaled 429 yards, intercepted Ryan Tannehill three times in the first half, and led 27-0 before Miami scored late in the third quarter.

The Bills improved to 5-2 against Miami over the past four years.