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Rod Beard: The Lions defense has shown an ability to bend but not break, but they’ve only faced one quarterback this season the caliber of Drew Brees. The balance of the Saints eventually wears down the Lions, who will miss Calvin Johnson for the second straight game. Saints 20-17

Josh Katzenstein: The Saints offense will score, but the Lions defense won’t let it be a shootout. In a game of strength on strength, the perceived weaknesses will likely determine the winner, and the Lions offense should be able to produce against a New Orleans defense allowing 28.2 points, 28th in the NFL. Lions 27-24

Bob Wojnowski: The Saints offense is scary, even without Jimmy Graham, and should help answer this question: Is the Lions defense legitimately scary? Drew Brees and the 2-3 Saints are desperate, and will be the toughest test for the Lions defense since Aaron Rodgers last month. If you’re legit, you have to show it every week. Lions 34-27

John Niyo: The Lions secondary gets its first real test of the season facing Drew Brees & Co. But without Jimmy Graham in the red zone, they should manage to hang in there. Lions 27-23