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It's the season opener and there's plenty of mystery. Detroit News reporters John Niyo and Justin Rogers break down what we know and what we don't. Justin Rogers, The Detroit News

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Allen Park — You know it's the regular season given how cagey the Detroit Lions have been with injury information this week. On Friday, the team filed its formal injury report with the league, listing four starters as questionable for Sunday's opener in Arizona against the Cardinals. 

Defensive tackle Da'Shawn Hand was downgraded to out Friday night. Linebacker Jarrad Davis, cornerback Rashaan Melvin and center Frank Ragnow are all questionable after being limited in practice throughout the week. 

Based on player participation during the portions of practice open to media, Davis seems less likely to play. Melvin upped his participation on Friday after minimal reps in individual drills earlier in the week, while Ragnow has looked closer to returning after suffering an ankle injury in the team's third preseason game. 

If Davis (ankle) can't play, it should lead to expanded playing time for both Jalen Reeves-Maybin and rookie Jahlani Tavai. With Melvin (knee), the Lions would likely look to Dee Virgin or Mike Ford to field more reps if the veteran is out. 

The only other Lions player to miss practice time this week, defensive end Trey Flowers, was a full participant on Friday and not listed on the final injury report.